For the past three to four decades, biocompatibility testing has stayed relativity unchanged; you follow a few simple steps: 1) look at your device 2) compare it to a chart 3) do the suggested testing. With the recent publication of ISO 10993-23, animal-free irritation testing is now being performed side by side with its animal counterpart. Current revisions to 10993-1 are emphasizing less animal testing and more alternative approaches. What are the proposed changes to 10993-1? What do regulators think about alternative testing approaches? Where is the future going, and how soon will we get there? These are the important questions we will discuss in this talk. Attendees will walk away with a clearer picture of the current alternatives to animal testing and what might happen next year, and the next few years to come.