The appropriate Cleaning and Disinfection validations on reusable devices are extremely important to ensure safe for handling by health care personnel and to prepare reusable medical devices for additional reprocessing.  The validations for these processes have been a hot discussion item for a few years with new and emerging information surfacing frequently.  Two of the most recent topics include validating devices that are non-patient contacting and simulated use of devices prior to the cleaning and disinfection validations.  This innovative brief with encompass this information as well as the basics of cleaning and disinfection validations.