The following poster was presented at the Extractables & Leachables session of the annual conference of American Society for Mass Spectrometry (ASMS) in Minneapolis.
Read the following abstract to learn more.
Routine E&L testing of medical devices requires extraction using three solvent systems with differing polarity: nonpolar (like hexane or DCM), mid-polar (like IPA), and polar (like water), which is usually followed by the mass spectrometry analysis. While GC-MS and LC-APCI-MS are conventionally used to analyze hexane extracts, there is a growing (and specific) demand for the analysis of hexane extracts by LC-ESI-MS. Hexane is considered one of the non-compatible solvents for the ESI due to its highly nonpolar nature. Therefore, we studied evaporation and reconstitution of selected E&L quality control chemical standards from hexane & IPA to different ESI-compatible solvents. Results show the possibility of achieving the desired analysis without losing the method’s analytical sensitivity and selectivity.
The authors employed by Nelson Labs are listed below. The other author is Benjamin Hunt.
