Some typical toxicological challenges in LVP E&L will be presented, such as difficulties in exposure evaluations due to low AET. On the other hand, typical difficulties in hazard and risk evaluations relate to data-poor substances typically seen from rubber stoppers on glass bottles and the variety of substances from polymer materials containing several sources of E&L. Based on these settings, some E&L examples were selected to discuss the critical toxicological endpoints and were evaluated by means of various methods, in terms of deriving appropriate safety limits

This presentation was recorded on March 24 and is part of a series.