Rubber Oligomers, originating from the rubber closure (vial) or plunger (e.g., syringe or cartridge) are a class of compounds that needs an increased level of attention, especially when they are chlorinated or brominated. These halogenated oligomer compounds have shown to be reactive to the drug product under certain circumstances, and toxicity is potentially of high
concern.
With this presentation, rubber oligomers’ structure will be discussed and how it pertains to their reactivity and toxicity. In addition, we will take a closer look at their formation and how you can detect these compounds and identify them in an extractable or leachable study.

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