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ON-DEMAND WEBINAR

ON-DEMAND WEBINAR

Reactive Leachables: Chemical Interaction between Leachables and Insulin / Therapeutic Proteins

Published Date: June 21, 2019

In-silico model combined with analytical proof of concept

Leachable compounds are currently only evaluated on the toxicological risk they pose to the patient. The effects that leachable compounds have on the quality and safety of pharmaceutical drug products, especially protein drug products, is often overlooked. Interactions of reactive leachable compounds with protein drug products can lead to a loss of efficiency, decrease of stability and increased immunogenicity in the patient population at risk. This webinar describes reactive leachable compounds, the scientific basis to predict leachable-protein interactions and a proof of concept.

By the end of this webinar you should know:

1. What reactive leachables and their risks are.
2. How reactive leachables can be predicted.
3. How to implement reactive leachables in your E&L studies.

Piet Christiaens

Piet Christiaens

PhD
Scientific Director

Piet Christiaens received his Ph.D. from the Analytical Chemistry Department of the University of Leuven (Belgium) in 1991. From 1992 to 1997, he was Lab Manager in two CROs. From 1997 to 2000, he worked as an independent consultant with Shell Chemical Company in Houston, Texas (US), working on hydrogenated triblock co-polymers. Since 2001, Piet...

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