USP/EP Water Tests

The current USP and EP both have multiple categories and requirements for different types of water. These include (most commonly) Purified Water, Sterile Purified Water, Water for Injection, and Sterile Water for Injection. Contact the Sales Department at sales@nelsonlabs.com for an abbreviated test set or specific water category quote.

Optional Tests for USP/EP Water Tests

Water for injection, USP

Water for injection is water which has been purified by distillation or a purification process that is equivalent or superior to distillation in the removal of chemicals and microorganisms.

The USP monograph requires:

• Bacterial Endotoxins (LAL)
• Conductivity
• TOC

Purified water, USP

Purified water is water which has been purified using unit operations that include deionization, distillation, ion exchange, reverse osmosis, filtration, or other suitable purification procedures.  It must meet requirements for ionic and organic chemical purity and be protected from microbial contamination.

The USP monograph requires:

• Conductivity
• TOC (Total Organic Carbon)

Study Outline

The United States Pharmacopeia (USP) has monograph specifications for nine different types of water. Other non-monograph waters may be tested upon request. Please refer to the individual water monograph descriptions. Click here for the USP water test matrix.

Sample Requirements

Water Type                                   Minimum Volume Required (mL)

Purified water....................................150
Sterile purified water..........................200 + sterility and B/F
Pure steam........................................155
Water for injection.............................155
Bacteriostatic water for injection.........450 + sterility and B/F
Sterile water for injection....................570 + sterility and B/F
Sterile water for inhalation...................205 + sterility and B/F
Sterile water for irrigation....................205 + sterility and B/F
Water for hemodialysis.........................235

Nelson Experts:

• Erin Bakes 801-290-7873, 800-826-2088

Sample Requirements

Water Type                                   Minimum Volume Required (mL)

Purified water....................................150
Sterile purified water..........................200 + sterility and B/F
Pure steam........................................155
Water for injection.............................155
Bacteriostatic water for injection.........450 + sterility and B/F
Sterile water for injection....................570 + sterility and B/F
Sterile water for inhalation...................205 + sterility and B/F
Sterile water for irrigation....................205 + sterility and B/F
Water for hemodialysis.........................235